Articles
A glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones – A new strategy to combat malarial parasites.
Müller, T.; Johann, L.; Jannack, B.; Brückner, M.; Lanfranchi, D. A.; Bauer, H.; Sanchez, C.; Yardley, V.; Deregnaucourt, C.; Schrével, J.; Lanzer, M.; Schirmer, R. H.; Davioud-Charvet, E.
Isomerization Mechanism in Hydrazone-Based Rotary Switches: Lateral Shift, Rotation, or Tautomerization ?
Landge, S. M.; Tkatchouk, E.; Benitez ; Lanfranchi, D. A.; Elhabiri, M.; D.; Goddard III, W. A.; Aprahamian I.
Highly stable acyclic bifunctional chelator for 64Cu PET imaging.
Abada, S.; Lecointre, A.; Déchamps-Olivier, I.; Platas-Iglesias, C.; Christine, C.; Elhabiri, M.; Charbonniere, L.J.
Radiochimica Acta 2011, 99, 663-678
Synthesis and New Properties of the Emerging Azacalix[14]arenes.
Touil, M.; Elhabiri, M.; Lachkar, M.; Siri, O
Electrostatic stabilization of rotaxanes and pseudorotaxanes.
THmadeh, M.; Fahrenbach, A. C.; Basu, S.; Trabolsi, A.; Benitez, D.; Li, H.; Albrecht-Gary, A. M.; Elhabiri, M.; Stoddart J. F.
Hydroxyquinoline based binders: promising ligands for chelato-therapy ?
Budimir, A.; Humbert, N.; Elhabiri, M.; Osinska, I.; Birus, M.; Albrecht-Gary A. M.
Enantioselective Access to Key Intermediates for Salvinorin A and Analogues.
Lanfranchi, D. A.; Bour, C.; Hanquet G.
Enantiomeric differentiation of Atropine [(+-)-Hyoscyamine] by 13C NMR spectroscopy and its application to Datura stramonium extract
Lanfranchi, D. A.; Tomi, F.; Casanova, J.
Ring-closing of 1,7- and 1,8-enynes of propargylic o,o-acetals by ruthenium-catalyzed intramolecular metathesis.
Lanfranchi, D. A.; Bour, C.; Boff, B.; Hanquet G.
Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.
Wenzel, N. I., Chavain, N., Wang, Y., Friebolin, W., Maes, L., Pradines, B., Lanzer, M., Yardley, V., Brun, R., Herold-Mende, C., Biot, C., Tóth, K., Davioud-Charvet, E.
Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker.
Chavain, N.; Davioud-Charvet, E.; Trivelli, X.; Mbeki, L.; Rottmann, M.; Brun, R.; Biot C.
Antitrypanosomal unsaturated Mannich bases active against multidrug-resistant T. brucei brucei strains.
Wenzel, I. N.; Wong, P. E.; Maes, L.; Müller, T. J. J.; Krauth-Siegel, L. R.; Barrett, M.; Davioud-Charvet E.
A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells.
Viry, E.; Battaglia, E.; Deborde, V.; Müller, T.; Réau, R.; Davioud-Charvet, E.; Bagrel D.
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase.
Morin, C., Besset, T., Moutet, J.-C., Fayolle, M., Brückner M, Limosin, D., Becker, K., Davioud-Charvet, E.
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
Friebolin, W.; Jannack, B.; Wenzel, N.; Furrer, J.; Oeser, T.; Sanchez, C. P.; Lanzer, M.; Yardley, V.; Becker, K.; Davioud-Charvet, E.
Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target.
Kuntz, A. N.; Davioud-Charvet, E.; Dessolin, J.; Sayed, A. A.; Califf, L. L.; Arnér, E. S. J.; Williams, D. L.
Selected publications 
Elisabeth Davioud-Charvet
A fluoro analogue of the menadione derivative 6-[2’-(3’-Methyl)-1’,4’-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.
Bauer, H., Fritz-Wolf, K., Winzer, A., Kühner, S., Little, S, Yardley, V., Vezin, H., Palfey, B., Schirmer, H., Davioud-Charvet E.
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases.
Urig, S., Fritz-Wolf, K., Réau, R., Herold-Mende, C., Toth, K., Davioud-Charvet, E., Becker, K.
5-Substituted tetrazoles as bioisosters of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials
Biot, C., Bauer, H., Schirmer, R.H., Davioud-Charvet, E.
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity
Davioud-Charvet, E., McLeish, M. J., Veine, D., Giegel, D., Arscott, L. D., Andricopulo, A. D., Becker, K., Müller, S., Schirmer, R. H., Williams, C. H., Kenyon, G. L.
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline
Davioud-Charvet, E., Delarue, S., Biot, C., Schwöbel, B., Böhme, C. C. Müssigbrodt, A., Maes, L., Sergheraert, C., Grellier, P., Schirmer, R. H., Becker, K.
Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives
Dessolin, J., Biot, C., Davioud-Charvet, E.
2- and 3-substituted-1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox-cycling activities and in vitro cytotoxicity
Salmon-Chemin, L., Buisine, E., Yardley, V., Kohler, S., Debreu, M.A., Landry, V., Sergheraert, C., Croft, S. L., Krauth-Siegel, L. R., Davioud-Charvet, E.
Evidence for the co-existence of glutathione reductase and trypanothione reductase in the nontrypanosomatid Euglenozoa: Euglena gracilis Z.
Montrichard, F., Le Guen, F., Laval-Martin, D.L., Davioud-Charvet, E.
FEBS Lett. 1999, 442, 29-33
Mourad El Habiri
Complexation of Iron(III) by Catecholate-Type Polyphenols
M. Elhabiri, C. Carrër, F. Marmolle, H. Traboulsi
Supramolecular Edifices and Switches Based on Metals
M. Elhabiri, A. M. Albrecht-Gary
Redox-Driven Switching in Pseudorotaxanes
A. Trabolsi, M. Hmadeh, N. M. Khashab, D. C. Friedman, N. Humbert, M. Elhabiri, H. A. Khatib, M. E. Belowich, A. Coskun, A. M. Albrecht-Gary, J. F. Stoddart
Molecular Tools for the Self-Assembly of Bisporphyrin Photodyads: A Comprehensive Physicochemical and Photophysical Studies
J. Brandel, A. Trabolsi, H. Traboulsi, F. Melin, M. Koepf, J. A. Wytko, M. Elhabiri, J. Weiss, A. M. Albrecht-Gary
Acid-Base Actuation of [c2]Daisy Chains
L. Fang, M. Hmadeh, J. Wu, M. A. Olson, J. M. Spruell, A. Trabolsi, Y.-W. Yang, M. Elhabiri, A. M. Albrecht-Gary, J. F. Stoddart
On the Thermodynamic and Kinetic Investigations of a [c2]Daisy Chain Polymer
M. Hmadeh, L. Fang, A. Trabolsi, M. Elhabiri, A.M. Albrecht-Gary, J.F. Stoddart
Formation of very Stable and Selective Cu(II) Complexes with a Non-Macrocyclic Ligand : Can Basicity Rivals with Pre-organization
S. Abada, A. Lecointre, C. Christine, M. Elhabiri, L.J. Charbonnière
Patents
Total synthesis of redox-active 1,4-naphthoquinones and metabolites, and their therapeutic use as antimalarial and schistomicidal agents.
Lanfranchi, D. A., Johann, L., Williams, D. L., Davioud-Charvet, E.
European Patent 2011, EP11305346
Dibenzylidene- and heteroarylideneacetone derivatives as kinetoplastideae parasiticides and their preparation, pharmaceutical compositions and use in the treatment of trypanosomiasis and leishmaniasis.
Davioud-Charvet, E.; Wenzel, I. N.; Müller, T. J. J.; Hanquet, G.; Lanfranchi, D. A.; Leroux, F.; Gendron, T.
1,4-Naphthoquinone derivatives, their preparation, pharmaceutical compositions, and use as antimalarial agents.
Davioud-Charvet, E.; Müller, T.; Bauer, H.; Schirmer, H.
Books
Subversive substrates of glutathione reductases from P. falciparum-infected red blood cells as antimalarial agents.
Davioud-Charvet, E.; Lanfranchi, D. A.
in Apicomplexan parasites – Molecular approaches toward targeted drug development, Ed.: K. Becker, volume 2, from the series Drug Discovery in Infectious Diseases, (Ed.: P. M. Selzer), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, ISBN 978-3-527-32731-7
Thesis
Synthèse de récepteurs macrocycliques fluorescents et propriétés complexantes de métaux lourds et de lanthanides.
26 Juin 2011
Bachir Bensenane
Synthesis and mechanism of 1,4-naphthoquinones as turncoat inhibitors of disulfide reductases affecting the redox equilibrium of schistosomes and malaria parasites.
20 Mai 2011
Laure Johann
Synthesis and Mechanism of Antiparasitic Mannich Base Derivatives Affecting the Redox Equilibrium of Trypanosomes and Malaria Parasites.
21 Septembre 2009
Nicole Wenzel
Novel 1,4-Naphthoquinones as Inhibitors of Human and Plasmodial Glutathione Reductase and as Antimalarial Drugs. Synthesis, Enzymology and Activity Evaluation.
12 Décembre 2008
Tobias Müller
Naphthochinone als Sabotage-Inhibitoren der glutathionreduktasen aus malaria-infizierten Erhythrozyten – Kinetische und kristallographische Analyse neuartiger Substanzen.
Février 2007
Winzer Andreas